Study Set Content:
another wet method
fluid bed processing
Dry method
Roll compactor-granulator
Slugging
Roll compactor-granulator
Powders are pressed into sheets by rollers
then they are granulated
Slugging
Powder-compress-slugs-granulate-granules
This will result to (blank) (basically
very fine powders) that must be
removed by sieving then
reprocessed into slugs
fines
dry mixture usually
composed of A+B
Effervescent Granulated Salts
citric acid and tartaric acid
A
Sodium bicarbonate (1:2:3:4)
B
when in contact with H 2 O,
rapidly release
CO2
crumbly and no firmness
Tartaric acid alone
Sticky
Citric acid alone
using granules or coarse particles of the mixed powders -
Decreased rate of solution
using granules or coarse particles of the mixed powders -
decreased rate of solution -
no violent and uncontrollable effervescence
1 molecule of water
present in each molecule
of citric acid acts as the
binding agent
Dry
Moistening agent is a
hydroalcoholic solution
Wet
Equipment must be acid-resistant
Dry
Water+alcohol
Hydroalcoholic
effervescent granules
Do not swallow (blank)
whole
Allow complete dissolution of
granules
Follow manufacturer’s instructions for
reconstitution
