Study Set Content:
Protectants and artificial tears
celluloses
Vasoconstrictors and ocular decongestants
“zoline”
Ophthalmic sterile solution Requirements:
Sterility
Preservation
Isotonicity
use of bacterial filters* or autoclaving
Sterility
Benzalkonium chloride (0.01%) and either polymyxin B sulfate (1,000 USP U/mL) or disodium EDTA (0.01% - 0.1%) are effective against most strains of
Pseudomonas.
osmotic equivalences of 0.6% to 2% has no marked discomfort to the eyes
Isotonicity
same osmotic pressure as 0.9% sodium chloride.
Boric acid 1.9%
pH of normal tears is about 7.4
Buffering
Viscosity optimal in the range of
15 to 25 cP
0.25 % methylcellulose* of 4,000 cP, or hydroxypropyl methylcellulose and polyvinyl alcohol
Viscosity
is best permeated by drugs w/ both lipophilic and hydrophilic characteristics
Cornea
usually in plastic eyedrop container
Packaging
should be sparkling clear and free of all particulate matter, have micronized particles
Ophthalmics
(Blank) form, they should not aggregate and must easily redistribute upon gentle shaking.
suspension
Antimicrobial preservative
< or equal to 30
emollient
5-15
Gel,vehicle aqueous
50-80
Gel,vehicle nonaqueous
< or equal to 30
Humectant
0.5-3.0
Ophthalmic formulation
