Both COX-1 and COX-2 promote the uptake of two

molecules of oxygen by cyclization of arachidonic acid to

yield a C 9 – C 11 endoperoxide C 15 hydroperoxide

 This product is PGG2, which is then rapidly modified by

the peroxidase moiety of the COX enzyme to add a 15-

hydroxyl group that is essential for biologic activity. This

product is