Study Set Content:
In platelets, which lack nuclei, COX-1 (the only isoform expressed
in mature platelets) cannot be restored via protein biosynthesis,
resulting in extended inhibition of
TXA 2 biosynthesis.
Aspirin (acetylsalicylic acid) inhibits prostaglandin (PG) synthesis by
transfer of its (blank) to a (blank)residue in the cyclooxygenase
(COX) active site.
acetyl group, serine
cannot be replaced that is why aspirin can
depress platelet aggregation for many days.
COX
First, (blank) of the
naturally occurring prostaglandins have been developed
stable oral or parenteral long-acting analogs
Second, enzyme inhibitors and receptor antagonists have
been developed to interfere with the synthesis or effects
of the eicosanoids.
The discovery of (blank)as a major source of inflammatory
prostanoids led to the development of selective COX-2
inhibitors to preserve the gastrointestinal and
renal functions directed through COX-1, thereby reducing toxicity
COX-2
Third, efforts at (blank)-to change the
polyunsaturated fatty acid precursors in the cell
membrane phospholipids and so change eicosanoid
synthesis-is used extensively in over-the-counter products
and in diets emphasizing increased consumption of
coldwater fish.
dietary manipulation
Altoprostadil
Prostaglandin F2a
Misoprostol
Dinoprostone
Trepostinil sodium
Carbosprost tromethamine
Epoprostenol
Iloprost
