Study Set Content:
technique/method of administration
Intervention
placebo
Comparator
morbidity, mortality
Outcomes
, usual/standard care
Comparator
active control
Comparator
quality of life
Outcomes
adverse events
Outcomes
duration/intervals of follow-up
Timing
primary,
Setting
inpatient,
Setting
specialty,
Setting
home care
Setting
evidence of internal validity should be () by evidence of external validity wherever appropriate and feasible to demonstrate that a technology works in real-world practice
complemented
The “best evidence” may be the best() evidence, i.e., the best evidence that is currently available and relevant for the evidence questions of interest.
available
refers to a group of statistical methods for combining the data or results of multiple studies to obtain a quantitative estimate of the overall effect of a particular technology on a defined outcome.
Meta-analysis
Evidence collected for HTA often includes studies with insufficient statistical power to detect any true treatment effects. • By combining the results of multiple studies, a meta-analysis may have sufficient() to detect a true treatment effect if one exists, or at least narrow the confidence interval around the mean treatment effect.
statistical power
AMSTAR
Assessment of Multiple Systematic Reviews) (Shea 2009)
CHEERS
(Consolidated Health Economic Evaluation Reporting Standards) (Husereau 2013)
CONSORT
(Consolidated Standards of Reporting Trials) (Turner 2012)
GRACE
(Good ReseArch for Comparative Effectiveness) (Dreyer 2014)
