Study Set Content:
prevents formation of C3 convertase, CD59 inhibits MAC
Decay accelerating Factor (DAF) and CD59
inhibits alternative pathway
Complement Factor H
causes vasoconstriction and bronchoconstriction, and at low concentrations it induces vasodilation and increased venular permeability
Platelet-Activating Factor
cleavage products of fibrin (fibrinopeptides) can stimulate inflammation
Products of Coagulation
vasoactive peptides derived from plasma proteins, called kininogens
Kinins
increases vascular permeability and causes contraction of smooth
muscle, dilation of blood vessels, and pain
Bradykinin
secreted by sensory nerves and various leukocytes and may play a role in the initiation and regulation of inflammatory responses
Neuropeptides
Examples of Neuropeptides
Substance P and Neurokinin A
Give the reaction of Inflammation based on the Principal Mediators:
Histamine & Prostaglandins
Vasodilation
Give the reaction of Inflammation based on the Principal Mediators:
Histamine and Serotonin, C3a and C5a, Leukotrienes C4, D4, E4
Increased vascular permeability
Give the reaction of Inflammation based on the Principal Mediators:
TNF, IL-1, Chemokines, C3a and C5a, Leukotriene B4
Chemotaxis, Leukocyte recruitment and activation
Give the reaction of Inflammation based on the Principal Mediators:
IL-1, TNF, and Prostaglandins
Fever
Give the reaction of Inflammation based on the Principal Mediators:
Prostaglandins, Bradykinin, Substance P
Pain
Give the reaction of Inflammation based on the Principal Mediators:
Lysosomal enzymes of leukocytes, Reactive oxygen species
Tissue damage
