Basic Immunology Final; practice questions
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MCB 4211,
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12.
Telomerase is an important enzyme on which cancers depend since
a.
this enzyme maintains the ends of chromosomes and thus chromosomal stability
b.
this enzyme is an example of a kinase oncogene
c.
this enzyme activates apoptosis
d.
this is an angiogenic factor
e.
this enzyme is a lipase
13.
Why does anti-CD4 antibody treatment extend the average allograft survival time more than anti-CD8
antibody treatment?
a.
because anti-CD4 can kill macrophages
b.
because anti-CD4 will disrupt the contribution to many different immune mechanisms that
includes CTLs while anti-CD-8 only disrupts CTL function
c.
because anti-CD4 antibody is better at activating complement
d.
because anti-CD8 activity is an activator of helper T cell function
e.
none of the above are true
14.
What is a possible undesirable outcome of transplanting bone marrow to allogeneic recipients that have
had whole body irradiation to erase their own immune response?
a.
they can develop systemic lupus erythematosus
b.
they can develop DiGeorge syndrome
c.
they can develop a specific allergic phenotype to peanuts
d.
they can develop graft versus host disease
e.
all of the above are possible
15.
This question is related to the llama antibody paper. The authors used phage display to identify binding
partners for the
M. furfur
fungus. What technique was used to identify the original sequences that were
then used in the remainder of the study?
a.
they used ELISAs to purify the llama antibody that bound to
M. furfur
fungal protein
b.
they used phage display of llama V region genes to purify phage clones with the correct binding
profile for
M. furfur
protein
c.
they immunized a set of different llamas and then tested each by ELISA to identify the llama that
had randomly produced the best antibody profile
d.
they used surface plasmon resonance to measure antibody dissociation kinetics
e.
none of the above are correct
16.
In the recently announced Nobel prize for Medicine and physiology, Jim Allison was recognized for his
work with the CAR-T therapy that is now being used to treat human cancers of specific types. How
does this therapy work?
a.
Cytokines are injected into the patient to activate specific receptors producing an anti-tumor
response
b.
cytokines are used to activate host cells before they are reinjected into the patient
c.
immune cells are removed from the tumor, activated
in vitro
and then reinjected into the same
patient
d.
a donor immune cell is modified to attack host MHC class I that is expressed on the
patient’s
tumor. These cells are then injected into the patient to treat the cancer.
