Basic Immunology Final; practice questions
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MCB 4211,
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d.
Phytohemagglutinin (PHA)
e.
Interleukin-10 (IL-10)
23.
Which of the following HIV proteins is most important for final maturation of the HIV particle?
a.
Polymerase
b.
Protease
c.
Integrase
d.
Reverse transcriptase
e.
CCR5
24.
Which of the following classes of antiretroviral drugs prevents the conversion of viral RNA to DNA?
a.
Stem cell therapy
b.
Fusion inhibitors
c.
Nucleoside analogs
d.
Integrase inhibitors
e.
Protease inhibitors
25.
Which of the following assays is a surrogate for cell proliferation?
a.
3
H-thymidine incorporation assay
b.
Ames assay
c.
ELISA
d.
Phage display assay
e.
Boyden chamber assay
26.
Which of the following therapies would NOT be likely to enhance graft survival in graft recipients?
a.
Total lymphoid irradiation
b.
Immunosuppressive drugs
c.
Elimination of passenger leukocytes from the transplanted tissue
d.
Blocking monoclonal antibodies (against IL-2R, for example)
e.
Adjuvant therapy
27.
A patient with a MHC class II deficiency (an example is the Bare Lymphocyte syndrome):
a.
Will experience decreased viral susceptibility
b.
Will have an excess of activated complement that binds to MHC class II
+
cells
c.
Will experience declines in T
h
/APC interactions and a resulting immunodeficiency
d.
Will develop an autoimmune disease called Bare Lymphocyte Adenopathy (BLA)
e.
Will have decreased insulin levels
28.
What evidence is there that changes in gene regulation can cause cancer?
a.
EC cells from teratocarcinomas will continue to make cancer cells when transplanted into adult
mice
b.
EC cells from teratocarcinomas will produce normal tissue cells when transplanted into
blastocysts that are then implanted into pseudopregnant female mice for gestation.
c.
the Ames assay shows that mutagens are usually carcinogens
d.
Salmonella typhimurium histidine auxotrophs are able to revert to prototrophic growth after
exposure to mutagens
