Study Set Content:
Sedimentation Coefficient of IgE
8
Sedimentation Coefficient of IgD
7
Carbohydrate % of the following:
IgM -
IgG -
IgA -
IgE -
IgD -
IgM -12
IgG - 8
IgA - 7
IgE - 12
IgD - 12
Subclasses:
IgM -
IgG -
IgA -
IgE -
IgD -
IgM -none
IgG - IgG1-4
IgA -a1, a2
IgE - none
IgD - none
Serum concentration, adult (mg/dL)
IgM -
IgG -
IgA -
IgE -
IgD -
IgM -1.5
IgG -13.5
IgA - 3.5
IgE - 0.05
IgD - Trace
Serum half-life
(days)
IgM -
IgG -
IgA -
IgE -
IgD -
IgM - 5
IgG - 23
IgA - 6
IgE - 2.5
IgD - 3
Heavy Chain:
IgG -
IgM -
IgA -
IgD -
IgE -
IgG - γ
IgM - μ
IgA - α
IgD - δ
IgE - E
Valency:
IgG -
IgM -
IgA -
IgD -
IgE -
IgG - 2
IgM - 5 (10)
IgA - 2,4
IgD - 2
IgE - 2
% Total Ig:
IgG -
IgM -
IgA -
IgD -
IgE -
IgG - 75
IgM - 5-10
IgA - 15
IgD - 0-1
IgE - 0-1
Activates complement
A. Classical
IgG -
IgM -
IgA -
IgD -
IgE -
IgG - ++
IgM - +++
IgA - (-)
IgD - (-)
IgE - (-)
Activates Complement
B. alternative
IgG -
IgM -
IgA -
IgD -
IgE -
IgG - (-)
IgM - (-)
IgA - +
IgD - (-)
IgE - (-)
Crosses Placenta:
IgG -
IgM -
IgA -
IgD -
IgE -
IgG - ++
IgM - (-)
IgA - (-)
IgD - (-)
IgE - (-)
Binding to Phagocytes:
IgG -
IgM -
IgA -
IgD -
IgE -
IgG - +++
IgM - +
IgA - (-)
IgD - (-)
IgE - +
Most abundant Ig of internal body fluids particularly extravascular where it combats microorganisms and their toxins
IgG
Very effective agglutinating antibody; produced early in immune response
IgM
Protection of external body surfaces. Responsible for symptoms of atopic allergy
IgE
Mostly present on lymphocyte surfaces
IgD
Distribution: All variants present in serum of a normal individual
Isotypic
Distributic: Alternative forms; genetically controlled so not present in all individuals
Allotypic
Distribution: Individually specific to each immunoglobulin molecule
Idiotypic
