Study Set Content:
Step 4
Dissociation of agonist from internalized receptors reduces β-
Arr binding affinity, allowing (blank) of receptors
dephosphorylation
Dissociation of agonist from internalized receptors reduces β-
Arr binding affinity, allowing dephosphorylation of receptors by a
phosphatase (P’ase).
Return of Receptors to the plasma membrane together,
these events result in the efficient (blank) of cellular
responsiveness.
resensitization
Repeated or prolonged exposure of cells to agonists favors the
delivery of internalized receptors to
lysososomes
Step 6
Promoting receptor (blank)rather than
resensitization.
down-regulation
mediates such hormonal response as the mobilization of
stored energy
Cyclic Adenosine Monophosphate (cAMP)
cAMP mediates such hormonal response as the mobilization of
stored energy (the breakdown of(blank) in liver or
(blank) in fat cells stimulated by (blank)
carbohydrates, triglycerides, β-adrenomimetic
catecholamines),
mediates such hormonal response as the mobilization of
stored energy (the breakdown of carbohydrates in liver or
triglycerides in fat cells stimulated by β-adrenomimetic
catecholamines), conservation of water by the kidney
(mediated by vasopressin), Ca 2+ homeostasis (regulated by
parathyroid hormone), and increased rate and contractile force
of heart muscle (β-adrenomimetic catecholamines).
cAMP
conservation of water by the kidney
(mediated by
vasopressin),
Ca 2+ homeostasis (regulated by
parathyroid hormone
hormone), and increased rate and contractile force
of heart muscle
(β-adrenomimetic catecholamines).
is promoted by cAMP
Bronchodilator
Intracellular levels of cAMP can be increased by
β-
adrenoceptor agonist,
Intracellular levels of cAMP can be increased by β-
adrenoceptor agonist, which increase the rate of its
synthesis by
adenylyl cyclase (AC) or by
phosphodiesterase (PDE) inhibitors
cAMP inhibits (blank) that is
responsible for phosphorylating smooth muscle myosin
myosin light chain kinase
Therefore, increased in intracellular cAMP
which is caused by(blank) since it inhibits
myosin light chain kinase producing less contractile
force.
β-2 agonist
Less contractile force =
Relaxation
Overall function of cAMP is
intracellular signal induction
Overall function of cAMP is intracellular signal induction
ex.
Aminophylline, Theophylline
Phosphoinositides and Calcium
Involves hormonal stimulation of
phosphoinositide hydrolysis
