certain steroids (ethinyl estradiol,

norethindrone, and spironolactone);

fluroxene;

• Allobarbital

• the analgesic sedatives

allylisopropylacetylurea, diethylpentenamide,

and ethchlorvynol;

• carbon disulfide;

• grapefruit furanocoumarins;

• selegiline;

• phencyclidine;

• ticlopidine and clopidogrel;

• ritonavir; and propylthiouracil.

• secobarbital is found to inactivate CYP2B1

by modification of both its heme and protein

moieties