Study Set Content:
cholinergic transmission
Acetylcholine
adrenergic transmission
Norepinephrine
ANS drug achieve their effects by acting as either agonists or antagonists at cholinergic and adrenergic receptors. Six signal compounds:
1. Norepinephrine
2. Acetylcholine
3. Dopamine
4. Serotonin
5. Histamine
6. GABA (gamma amino butyric acid)
They are the most common involve in the actions of therapeutically useful drugs. Each of this chemical signals binds to the specific family of
receptors
are the primary chemical signals in the ANS.
Acetylcholine and norepinephrine
Autonomic nerve fibers can be divided into two groups based on the chemical nature of neurotransmitter release: o If mediated by Acetylcholine the neuron is termed as
cholinergic.
mediates the transmission of nerve impulses across the autonomic ganglia that involves the sympathetic and parasympathetic nervous systems.
Acetylcholine
Autonomic nerve fibers can be divided into two groups based on the chemical nature of neurotransmitter release: o If mediated by Acetylcholine the neuron is termed as cholinergic. Acetylcholine mediates the transmission of nerve impulses across the autonomic ganglia that involves the sympathetic and parasympathetic nervous systems. It is the neurotransmitter at the
adrenal medulla
It is the neurotransmitter at the
adrenal medulla
• The terminals and varicosities of cholinergic neurons contain large numbers of (blank) concentrated near the synaptic portion of the cell membrane
small membrane-bound vesicles
The terminals and varicosities of cholinergic neurons contain large numbers of small membrane-bound vesicles concentrated near the synaptic portion of the cell membrane as well as a smaller number of (blank) located farther from the synaptic membrane.
large dense-cored vesicle
The large vesicles contain a high concentration of
peptide cotransmitters.
The smaller clear vesicles contain most of the
acetylcholine.
Vesicles are initially synthesized in the neuron cell body and carried to the terminal by
axonal transport
They may also be recycled several times within the
terminal
are provided with vesicle-associated membrane proteins (VAMPs)
VESICLES
• which serve to align them with release sites on the inner neuronal cell membrane and participate in triggering the release of transmitter
Vesicle-associated membrane protein
• The release site on the inner surface of the nerve terminal membrane contains
synaptosomal nerve-associated proteins (SNAPs),
The release site on the inner surface of the nerve terminal membrane contains synaptosomal nerve-associated proteins (SNAPs), which interact with
VAMPS
is synthesized in the cytoplasm from acetyl-CoA and choline through the catalytic action of the enzyme choline acetyltransferase (ChAT).
ACETYLCHOLINE •
