Study Set Content:
The potencies of some antibiotics, endocrine products,
vitamins, products derived through biotechnology, and
biologics (e.g., vaccines) are based on their activity and
are expressed in terms of units (of activity), in
micrograms per milligram (mcg/mg), or in other
standardized terms of measurement.
In general, they conform also to international standards
defined by the World Health Organization and termed
International Units
is a measure of drug activity
expressed in terms of the amount required
to produce an effect of given intensity
potency
refer to the quantity of drug necessary to
produce a given effect, or it may refer to
the maximum response which can be
achieved with the drug
Potency
Degrees of activity are determined by
comparison against a suitable working standard,
generally a
USP Reference Standard.
authentic specimens used as
comparison standards in compendial tests and
assays
Reference
standards
The activity or potency of antibiotics is
determined by their
inhibitory effect on
microorganisms.
Is their a relationship between the unit of potency of one drug and the unit of potency of another drug.
No
can occur when a medication
order abbreviates the term units with a U and
places it after the number of units, since a poorly
written U can be mistaken for a zero
Dispensing errors
are preparations produced from a living source. They
include vaccines, toxoids, and immune sera, used for the
development of immunity, or resistance to disease;
certain antitoxins and antivenins, used as treatment
against specific antigens; and, toxins and skin antigens,
used as diagnostic aids.
Biologics
human serum
immune globulin
horse serum
tetanus antitoxin
chick cell culture
measles virus vaccine
a bacterial vaccine commonly is expressed in
terms of
micrograms (mcg) or units of antigen
per milliliter
viral vaccine is expressed most commonly in
terms of
tissue culture infectious dose
(TCID50), which is the quantity of virus
estimated to infect 50% of inoculated cultures.
generally expressed in terms of
flocculating units (Lf Unit)
flocculating units
Lf unit
1 Lf Unit having
the capacity to flocculate or precipitate
one unit
of standard antitoxin.
Any atom or molecule with a net charge, either
positive or negative
Ions
substances that are not dissociated in
solution
Non-electrolytes
