Pharmacology MCQs: Antihypertensives, vasodilators, angina drugs,
cardiac glycosides.
1. Diuretics
a. Work to lower BP initially by decreasing peripheral vascular
resistance
b. Thiazide diuretics are potassium sparing
c. Are effective in lowering Bp by 20 – 25 mmHg in most patients
d. BP response to thiazides continues to increase at doses greater
than usual therapeutic dose.
e. Diuretics may impair glucose tolerance
2. Methyl dopa
a. Lowers the heart rate and cardiac output more than clonidine
does
b. Causes reduction in renal vascular resistance
c. Has minimal CNS side effects
d. Has 80% bioavailability
e. Usual therapeutic dose is about 1 – 2 mg/day
3. Propranolol
a. Is a B1 specific blocker
b. Causes prominent postural hypotension
c. Inhibits the stimulation of renin production by catecholamines
d. Has a half life of 12 hours
e. Has no effect on plasma lipids
4. Hydralazine
a. Dilates veins but not arterioles
b. Is contraindicated in the treatment of preeclampsia
c. Can cause an SLE type syndrome in up to 10 – 20% of patients
d. Causes orthostatic hypotension in many cases