Pharmacrystal

www.pharmacrystalniper.blogspot.com

www.pharmacrystalniper.blogspot.com

10

acidification of the urine?
        a) Weak acid with pKa of 5.5
        b) Weak acid with pKa of 3.5
        c) Weak base with pKa of 7.5
        d) Weak base with pKa of 7.1
6.4) A patient diagnosed with type 2 diabetes is administered an oral dose of 0.1 mg
chloropropamide, an insulin secretagogue and weak acid with a pKa of 5.0. What is the
amount of this drug that could be absorbed from the stomach at pH 2.0?
        a) 99.9 µg
        b) 90 µg
        c) 50 µg
        d) 0.05 mg
        e) 0.01 mg