Quality Standards and Compendial Requirements for Semi-Solid Dosage Forms Ointments and Creams
Control Tests
• Organoleptic evaluation
• Assay for active ingredients
• Test of rate of absorption
• Test for non-irritancy
• Test of rate of penetration
• Test of rate of drug release
• Test of rheological properties
• Test of content uniformity
• ID test for the active ingredients and possible contaminants
• Loss of water/water content
• pH + Sterility test
• Storage condition
• Stability test
• Minimum Fill
• Metal Particles in ophthalmic ointments
• Microbial Content