Study Set Content:
is a consequence of the decrease in
cardiac output that results from bradycardia.
hypotension
Serotonin has a(blank) effect on
bronchiolar smooth muscle in normal humans,
small direct stimulant
Serotonin has a small direct stimulant effect on
bronchiolar smooth muscle in normal humans, probably
via
5-HT 2A receptors.
It also appears to facilitate (blank) from bronchial vagal nerve endings.
acetylcholine release
In patients with carcinoid syndrome, episodes of
(blank) occur in response to elevated
levels of the amine or peptides released from the tumor.
bronchoconstriction
Serotonin may also cause (blank) as a result
of the chemoreceptor reflex or stimulation of bronchial
sensory nerve endings.
hyperventilation
Serotonin directly causes the (blank) of vascular
smooth muscle, mainly through (blank)
In humans, serotonin is a powerful (blank)
except in skeletal muscle and the heart, where it dilates
blood vessels.
contraction , 5-HT 2 receptors , vasoconstrictor
Serotonin also constricts veins, and (blank) with
increased capillary filling appears to be responsible for the
flush that is observed after serotonin administration or
release from a carcinoid tumor.
venoconstriction
is a powerful stimulant of gastrointestinal
smooth muscle, increasing tone and facilitating peristalsis.
Serotonin
This action is caused by the direct action of serotonin on
(blank) plus a stimulating action
on (blank) located in the enteric nervous system. 5-
5-HT 2 smooth muscle receptors, ganglion cells
may also be involved in this
complex action.
5-
HT 1A and 5-HT 7 receptors
Activation of (blank)in the
enteric nervous system causes increased acetylcholine
release and thereby mediates a motility-enhancing or
"prokinetic" effect of selective serotonin agonists such as cisapride
5-HT 4 receptors
in
carcinoid tumor is associated with severe diarrhea.
Overproduction of serotonin
are present on skeletal muscle
membranes, but their physiologic role is not understood.
5-HT2 receptors
is a condition associated with skeletal
muscle contractions and precipitated when MAO inhibitors
are given with serotonin agonists, especially
antidepressants of the selective serotonin reuptake
inhibitor class (SSRIs).
Serotonin syndrome
Studies in animal models of glaucoma indicate that 5-HT
2A agonists reduce
intraocular pressure.
Studies in animal models of glaucoma indicate that 5-HT
2A agonists reduce intraocular pressure. This action
can be blocked by (blank) and similar 5-HT 2
antagonists.
ketanserin
has no clinical applications as a drug. However,
several receptor subtype-selective agonists have proved
to be of value.
Serotonin
5-HT 1A agonist, has received wide
attention for its usefulness as an effective
nonbenzodiazepine anxiolytic.
Buspirone,
another selective 5-HT agonist, was
widely used as an appetite suppressant but was
withdrawn because of cardiac valve toxicity.
Dexfenfluramine,
