Study Set Content:
a 5-HT 4 partial agonist, is used for irritable
bowel syndrome with constipation.
Tegaserod,
which modulate
serotonergic transmission by blocking reuptake of the
transmitter, are among the most widely prescribed drugs
for the management of depression and similar
disorders.
Fluoxetine and other SSRIs,
is clearly desirable in those rare patients who
have carcinoid tumor and may also be valuable in certain
other conditions.
SEROTONIN ANTAGONISTS:
As noted, serotonin synthesis can be inhibited by (blank). However,
these agents are too toxic for general use.
Storage of serotonin can be inhibited by the use of
(blank), but the sympatholytic effects of this drug and
the high levels of circulating serotonin that result from
release prevent its use in carcinoid.
p-
chlorophenylalanine and p-chloroamphetamine , reserpine
Therefore, (blank) is the major therapeutic
approach to conditions of serotonin excess.
receptor blockade
eg, a adrenoceptors,(blank), have
serotonin receptor-blocking effects.
H 1-histamine receptors
has a long-lasting blocking action
at 5-HT 2 receptors.
Phenoxybenzamine
resembles the phenothiazine
antihistaminic agents in chemical structure and has potent
H 1-receptor-blocking as well as 5-HT 2-blocking actions.
Cyproheptadine
-It prevents the smooth muscle effects of both amines but
has no effect on the gastric secretion stimulated by
histamine.
-It also has significant antimuscarinic effects and causes
sedation.
Cyproheptadine
Cyproheptadine treatment of the smooth muscle manifestations of
carcinoid tumor and in
cold- induced urticaria.
The usual dosage in adults is
12-16 mg/d in three or four
divided doses.
It is available only in tablet form,
cyproheptadine must be (blank) and administered by
stomach tube in unconscous patients.
crushed
blocks 5-HT 2 receptors on smooth muscle
and other tissues and has little or no reported antagonist
activity at other 5-HT or H 1 receptors.
Ketanserin
The drug blocks (blank) on platelets and
antagonizes platelet aggregation promoted by serotonin.
5-HT 2 receptors
The mechanism involved in ketanserin's hypotensive
action probably involves a 1 adrenoceptor blockade more
than
5-HT 2 receptor blockade.
another 5-HT 2 antagonist, has little or no a-
blocking action. It has been reported to alter bleeding time
and to reduce thromboxane formation, presumably by
altering platelet function.
Ritanserin,
is the prototypical 5-HT 3 antagonist. - the
prevention of nausea and vomiting associated with
surgery and cancer chemotherapy.
Ondansetron
a fungus that infects grasses and
grains-especially rye-under damp growing or storage
conditions.
Claviceps purpurea,
This fungus synthesizes histamine,
acetylcholine, tyramine, and other biologically
active products in addition to a score or more of
unique ergot alkaloids.
Claviceps purpurea,
These alkaloids affect
a adrenoceptors,
dopamine receptors, 5- HT receptors,
