OECD Test guideline 452:
Rodents
OECD Test Guideline 453
rats or mice
442 -C Appendix I
Direct Peptide Reactivity Assay
442-C Appendix II
Amino Acid Derivative Reactivity Assay (ADRA)
442 -D
ARE-Nrf2Luciferase KeratinoSens™ TestMethod
Appendix 1B
ARE-Nrf2LuciferaseLuSens TestMethod
OECD 442-D Appendix 1C
Epidermal Sensitisation Assay (EpiSensA)
0-0.03
No irritation
0.04-0.99
Irritation barely perceptible
1.00-1.99
Slight irritation
2.00-2.99
Mild Irritation
3.00-5.99
Moderate Irritation
6.00-8.00
Severe Irritation
redness of skin as a result of increased local blood flow.
Erythema
accumulation of fluid in subcutaneous and interstitial spaces
Edema
dead tissue that shed or falls off from healthy skin
Eschar