Study Set Content:
CO2 from bicarbonate and NH4 from the two sources mentioned above combine together in the liver mitochondria to form carbamoyl phosphate in presence of
ATP and Mg2+
CO2 from bicarbonate and NH4 from the two sources mentioned above combine together in the liver mitochondria to form carbamoyl phosphate in presence of ATP and Mg2+ by the enzyme
Carbamoyl phosphate synthetase I (CPSI).
. Carbamoyl phosphate reacts with
ornithine
Carbamoyl phosphate reacts with ornithine transferring the
carbamoyl moiety
Carbamoyl phosphate reacts with ornithine transferring the carbamoyl moiety to produce
citrulline
Carbamoyl phosphate reacts with ornithine transferring the carbamoyl moiety to produce citrulline: by the enzyme i.e.
ornithine transcarbomylase
is formed by the reaction of Aspartic acid and citrulline:
Argininosuccinic acid
Argininosuccinic acid is formed by the reaction of Aspartic acid and citrulline: the NH2 group of the former is linked to
– CO group of the latter.
. Argininosuccinic acid is formed by the reaction of Aspartic acid and citrulline: the NH2 group of the former is linked to – CO group of the latter. The enzyme reqused is
argininosuccinic acid synthase.
Argininosuccinic acid is cleaved to form
Arginine and fumerate
Argininosuccinic acid is cleaved to form Arginine and fumerate by the enzyme
Arginosuccinate lyase
goes to the pool of TCA-cycle.
Fumarate
Arginine gets cleared off to
urea and ornithine
. Arginine gets cleared off to urea and ornithine by the cytosolic enzyme
arginase
Arginine gets cleared off to urea and ornithine by the cytosolic enzyme arginase. Ornithine is thus re-generated and can be transported in to the mitochondrion to initiate another round of the
Urea-cycle
