Study Set Content:
HCl,
pH adjuster
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Citric acid
Buffer
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H2SO4
pH adjuster
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citric acid
pH adjuster
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Na citrate/acetate/lactate/phosphate
Buffer
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Na hydroxide/bicarbonate/citrate
pH adjuster
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Tonicity adjusters o Adjusters can be
NaCl, mannitol, dextrose
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Isotonicity required for IV, and ideal for subQ, ID, IM, intrathecal and intraocular
Tonicity adjusters
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Suspending agent o For IM and IA injectable suspensions -
cellulose derivatives
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polysorbates
Suspending agents
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• autoclave
Steam or moist
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under pressure
Steam or moist
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oven
Dry heat
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Millipore or sieve
Filtration
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denaturation & coagulation of protein
Steam or moist
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keeps things dry
Dry heat
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physical removal
Filtration
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dehydration then slow oxidation
Dry heat
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for non-aqueous prep
Dry heat
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NOT for oily prep and exposed powders
Steam or moist
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Study Set Content:
HCl,
FLASHCARD
Citric acid
FLASHCARD
H2SO4
FLASHCARD
citric acid
FLASHCARD
Na citrate/acetate/lactate/phosphate
FLASHCARD
Na hydroxide/bicarbonate/citrate
FLASHCARD
Tonicity adjusters o Adjusters can be
FLASHCARD
Isotonicity required for IV, and ideal f...
FLASHCARD
Suspending agent o For IM and IA injecta...
FLASHCARD
polysorbates
FLASHCARD
• autoclave
FLASHCARD
under pressure
FLASHCARD
oven
FLASHCARD
Millipore or sieve
FLASHCARD
denaturation & coagulation of protein
FLASHCARD
keeps things dry
FLASHCARD
physical removal
FLASHCARD
dehydration then slow oxidation
FLASHCARD
for non-aqueous prep
FLASHCARD
NOT for oily prep and exposed powders
FLASHCARD
