Study Set Content:
2nd step
Radio labeled drug/ formulation
3rd step
In vitro/In vivo quality check(labeling efficiency)
4th step
scanning under a gamma camera
last step
scintigraphs
Radio labeled drug/ formulation
In vitro/In vivo quality check(labeling efficiency)
scanning under a gamma camera
scintigraphs
example of type a gelatin
pig skin gelatin
example of type b gelatin
bovine gelatin
example of another type a gelatin
fish skin gelatin
When combined with pK studies, a (blank) provides info on transit and drug-release patterns of the DF
pharmacoscintographic evaluation
When combined with pK studies, a pharmacoscintographic evaluation provides info on transit and drug-release patterns of the DF and rate of drug absorption from the various regions of the
gastrointestinal tract
non- radioactive
Heidelberg Capsule
a pH-sensitive nondigestible radiotelemetric device approximately in No. 0 gelatin capsule size
Heidelberg Capsule
heidelberg capsule measures?
s gastric pH, gastric residence time, and gastric emptying time of solid dosage forms in fasting and nonfasting human subjects
steps in manufacture of HGC shells
1Dipping
2Drying
3Trimming
Dipping of pegs into the melted gelatin mixture
Dipping
trimming of capsule parts into proper length & removing from pegs
Trimming
The gelatin is dried by gentle flow of air
Drying
