Study Set Content:
Kapseal
Pulvule
spansule
Grooves lock the two halves together once the capsule has been filled
Snap-fit
Tapered rim to avoid telescoping
Coni-snap
indentions to prevent premature opening
Snap-fit
largest capsule
 000
smallest capsule size
5
Choose the size depending on the
 amount of material to be encapsulated
Larger capsules are available for
veterinary use
Rule of thumb
Use the smallest capsule size as much as possible
Dilluent or filler
Lactose
microcrystalline cellulose
starch
Lubricant/glidant
stearates, stearic acid
fumed silicon dioxide
talc(0.25% to 1%)
Disintegrants
pregelatinized starch
croscarmellose
sodium starch glycolate
To achieve uniform drug distribution, it is advantageous if the (blank)of the drug and excipients are similar.
density & particle size
for drug dose of 10 mg or more
Milling
for drug dose less than 10 mg
Micronization
Feed funnel
compressed feed air or gas inlet
compressed grind air or gas
