Caffeine
• Joseph Pelletier and Pierre Robiquet
- separated codeine from opium.
• Pierre Robiquet
when was Philadelphia College of Pharmacy created
1821
United States Pharmacopeia was created to establish drug standards.
1820
Early Research (cont.)
• Joseph Pelletier and Pierre Robiquet
• Pierre Robiquet
• Philadelphia College of Pharmacy, 1821
• 1820, United States Pharmacopeia was created to establish drug standards.
Pharmakon
drug
to make
Poiein
to make drugs
Pharmacopeia
– includes detailed monograph of drug substances and their dosage forms
USP
– includes detailed monograph of pharmaceutic ingredients
NF
No accepted medical use: high abuse potential
Schedule I
Accepted medical use: high abuse potential leading to severe psychological or physical dependence
Schedule II
Accepted medical use:low potential for abuse relative to III: may lead to limited psychological or physical dependence
Schedule IV
Accepted medical use: less abuse potential than II leading to moderated psychological or physical dependence
Schedule III
Accepted medical use: low potential for abuse relative to IV: may lead to limited psychological or physical dependence
Schedule V
Comprehensive Drug Abuse Prevention and Control Act of 1970
Schedule I
Schedule II
Schedule III
Schedule IV
Schedule V
studies show safe for fetus
Category A
no fetal studies, no risk in animal
• Category B
– harm on animal, but benefit>risk
Category C
harm on fetus, but benefit>risk
Category D