10%
>12 yr. old
clear syrupy liquid with a sweet taste, less viscous with heating
Glycerin, USP (Glycerol)
viscous, miscible with water and alcohol
Propylene glycol
used as stabilizer and auxiliary solvent
Glycerin, USP (Glycerol)
used as auxiliary solvent
Propylene glycol
USES OF GLYCERIN
anti microbial preservative
emollient
5.0-15.0
gel vehicle, aqueous
50.0 - 80.0
gel vehicle, non-aqueous
humectant
0.5-3.0
ophthalmic formulations
variable
patch additive
variable
plasticizer in tablet film coating
solvent for parenteral formulations
variable
plasticizer in tablet film coating
sweetening agent in alcoholic elixirs
Usual components of a pharmaceutical solution
Active ingredient
Solvent
Colorants, Flavorants, Sweeteners
Preservatives, Antioxidants, Chelating agents, pH/isotonicity adjusters
Solubility is a
must
Provides the therapeutic effect
Active ingredient
Must dissolve the API and must be suitable for the ROA
Solvent