Study Set Content:
quantitative amount administered or taken by a patient for the intended medicinal effect
Dose
amount taken at one time
Single Dose
can be subdivided into DIVIDED DOSES- two or more times per day
Daily Dose
the amount taken during the course of therapy
Total Dose
schedule of dosing
Dosage regimen
Factors affecting the safety of the dose
- Weight and condition of the patient
- Dosage form prescribed
- Age
- Possible influence of the other drugs being taken
- The frequency of administration
Available Guides For Pharmacist In Evaluating The Safety Of Prescribed Dose
USP Dispensing Information
Manufacturer's Catalog, File
- Cards & Package:
Physician’s Desk Reference
AMA Drug devaluations
American Hospital
Formulary Services Drug Information, facts and Comparisons
Pediatric Dosage Hand
Problem may arise when a reasonable dose is administered too
frequently
The dose of each ingredient should be calculated and its
safely verified
Dose should be calculated because the safety of the prescription may depend on the
requency of administration as well as the size of each dose
Before the pharmacist attempts to compound a prescription. - He should see to it that there is no danger of an over
dosage or incompatibilities.
Any portion of the prescription not clearly understood should be consulted to the
prescriber
It must be emphasized that in the event of injuries or fatalities resulting from over dosage of drugs, the pharmacist can be held
criminally liable
Factors Affecting The Dose
The Increasing potency and complexity of modern drugs
Optimum dose for a particular patient
have increased the importance of exact determination of dosage.
The Increasing potency and complexity of modern drugs
highly individualistic
Optimum dose for a particular patient
Must be determined by the physician after careful analysis of the patient’s history, examination, and diagnosis
Optimum dose for a particular patient
THE OPTIMUM DOSE IS DEPENDENT ON:
1. History and examination
2. Diagnosis
3. Patient’s environment
type and severity of the disease, presence of the pathological conditions
Diagnosis
age, sex, weight, body surface area, previous illnesses, emotional state, tolerance, and idiosyncrasy.
History and examination
