Study Set Content:
Combination of drugs may require altered dosage of individual drugs, lower in case of additive or synergistic combination, higher in case of
antagonistic combination.
Particularly good reason may lead a doctor to give an apparent overdose of a drug and perhaps intends the dose he has
prescribed
Nevertheless, the pharmacist should consult the (blank)to clarify that the dose is safe. There many factors involved concerning the safety of a given dose that physician alone knows.
prescriber
usually requires a greater quantity of a sedative than a normal person.
nervous person
usually requires a quantity of a stimulant that seems abnormally large.
Phlegmatic person
may exist in the patient who may have been taking one sedative for some time and has developed a tolerance for other member sedatives of the group as well as the one taken.
Cross tolerance
sometimes demand larger doses of certain drugs. There may be unusually large amount of pain accompanying the condition and abnormally large doses of narcotic may be required.
Pathological conditions
is an unusual response to an average dose of a drug.
Idiosyncrasy
Idiosyncrasy can be
Over-response
- Under-response
which is abnormal susceptibility
Over-response
which is abnormal tolerance; different action which has opposite action than what is expected like stimulation instead of depression
Under-response
sometimes acts as a stimulant in young hysterical girls producing delirium); developments of abnormal symptoms
morphine
the development of tolerance for other drugs after taking certain drugs with similar effects for a certain period of time.
Cross tolerance
An example is the tolerance developed for one sedative frequently leads to tolerance for another
sedatives
Alcoholics requiring larger amounts of (blank) than the non- alcoholics
anesthetic
when two drugs having similar actions are given together, one enhances the action of the other producing more pronounced effect than would be obtained with either drugs given alone. This permits the giving doses of each drug.
Synergism
(blank) of codeine (30mg) and ASA (0.3g) will have a greater effect than codein (60mg) and ASA (0.6g) individually
Combination
require smaller dosage of drugs than men
women
and thin patients needs (blank) dosage then heavy ones
less
They may likewise alter the usual dosage requirements.
Nature And Severity And Duration Of Illness
