Study Set Content:
The result of an effect to interfere with the elimination of a drug and thus, to (blank) the concentration
increase
Result from an effect on penetration or on the responsivity of the
efffector system
πππ‘βππππ‘ππππ πππππ:
1 + 1 = 3 ππ 1 + 1 => 2
Β are individually toxic to the liver, but together they produce much more liver injury then the sum of their individual effects on the liver.
Carbon tetrachloride and ethanol
have a greater effect on the central nervous system (CNS)
Barbiturate drugs
Barbiturate drugs - have a greater effect on the central nervous system (CNS) be causing CNS (blank) when taken with general anesthetics, alcohol (acute consumption), narcotic analgesic (pain reliever), and other sedative hypnotic drugs.
depression
when two or more like drugs are combined
Addition or summation
Addition or summation maybe
Β intentional or unintentional
Addition or summation formula
1 + 1 = 2
Codeine and Acetaminophen work together to produce bette
pain alcohol
Alcohol and aspirin can both cause GI bleeding; taken to get their day greatly increase the
risk
occurs when one drug increases the action of another drug
Potentiation -
Drug that has mild effect, enhances the effect of a second drug.
Potentiation
potentiation formula
0 + 1 = 2
increases the effect of morphine
Hydroxyzine
ο· Opposite of synergistic effect
Antagonism
Result in therapeutic effect that is less than the effect of either drug alone because the second drug either diminishes or cancels the effects of the first drug.
ANTAGONISM
ANTAGONISM πππ‘βππππ‘ππππ πππποΏ½
1 + 1 = 0
reverses the action of heparin
protamine
antagonism example
Β Naloxone and Morphine
