These agents are prodrugs with an acid-resistance enteric coating to protect them from premature degradation by gastric acid
INHIBITION OF H’/K’ ATPASE PUMP (PPIs)
The coating is removed in the alkaline duodenum, absorbed and transported to the parietal cell canaliculus and converted to active form with cysteine residue of the H’ /K’ ATPase, forming
stable covalent bond.
OTHER DRUGS USED ▪ Mucosal protective agents ▪ Ex
Sucralfate (Iselpin
▪ Cytoprotectant agent, which prevents mucosal injury, reduces inflammation and healing existing ulcers ▪ Heals duodenal ulcers and is used in long - term maintenance therapy to prevent their recurrence.
Mucosal protective agents
produced by the gastric mucosa, inhibits secretion of HCI and stimulate secretion of mucous and bicarbonate.
Prostaglandins E.
A deficiency of prostaglandins is thought to be involved in the pathogenesis of
peptic ulcer
Effective only at higher doses that diminish gastric secretion
▪ Prostaglandins
▪ Prostaglandins CI
During pregnancy, it produces uterine contraction
ANTIMICROBIAL AGENTS
Amoxicillin or metronidazole plus clarithromycin or bismuth subsalicylate and metronidazole plus tetracycline plus a PPI administered for 2 weeks
GERD which has heartburn like sensation is not associated with H. pylori infection and does not respond to treatment with
antibiotics
DRUGS FOR MOTILITY DISORDERS
Cholinomimetics:
Macrolides:
D2 receptors blockers:
Cholinomimetics: Ex.
Bethanechol and Neostigmine
– MOA: Stimulates motilin receptors of the GIT
: Erythromycin
D2 receptors blockers:
Metoclopramide (plasil). Domperidone (Motilium), itopride (ganaton).
indigestible colloids that absorbs water until a sufficient bulk is reach to distend the colon and promote peristalsis
Bulk-forming laxative
Bulk-forming laxative
methylcellulose, cellulose, psyllium
Side effects:
bloating ang flatulence
surfactants that promote water and lipid penetration into the stool
Stool softeners
Stool softeners
Docusate and glycerin suppository
stimulates the ENS and colonic electrolyte and fluid secretion
Stimulants laxative