Study Set Content:
The decrease in surface area and damage in proteins are caused by:
- Thermal Injury
- Intrinsic abnormalities
- Immune hemolysis
Caused by thermal injury; Resulting to blebbing or vesicle formation of RBC membrane and it will decrease the surface area leading to a small size of RBC
Microspherocyte
Caused by intrinsic abnormalities; Genetic mutation causing microvesicle
formation
Hereditary spherocyte
RBC has the ability to close again to avoid cytoplasmic leakage. What protein is responsible for this to occur?
Spectrin
is freely permeable to water (aquaporin 1) and to anions (band 3)
Red Cell Membrane
major extracellular cation
Sodium
major intracellular cation
Potassium
If cation pumps are not working, it will increase in intracellular monovalent cations and water and it begins to swell (increase sodium inside) causing what to happen?
osmotic hemolysis
Types of Metabolic Pathways:
- Embden-Meyerhof Pathway (Anaerobic Pathway of Glucose Metabolism)
- Hexose Monophosphate Pathway/Shunt
- Methemoglobin Reductase Pathway/Shunt
- Rapoport-Luebering Pathway/Shunt
