Study Set Content:
Biologically active amines
HISTAMINE
Functions as neurotransmitter
HISTAMINE
HISTAMINE Found
non-neural tissues
HISTAMINE Have complex physiologic and pathologic effects through
multiple receptor subtypes, and are often released
locally
are
biologically active amines that function as neurotransmitters and are
also found in non-neural tissues, have complex physiologic and
pathologic effects through multiple receptor subtypes, and are often
released locally.
Histamine and serotonin
Together with endogenous peptides,
prostaglandins and leukotrienes, and cytokines, they constitute the (blank) group of drugs.
autacoid
Histamine was synthesized in (blank) and later isolated from
mammalian tissues.
1907
Histamine was isolated from many different tissues, and thus, its
name was based on the Greek word ‘histos’, which means
tissue
It was isolated from the fresh samples of liver and lungs.
Histamine
Chemically, histamine is a
hydrophilic molecule
Chemically, histamine is a hydrophilic molecule which is consist of
an
imidazole ring
Chemically, histamine is a hydrophilic molecule which is consist of
an imidazole ring and an
amino group
Chemically, histamine is a hydrophilic molecule which is consist of
an imidazole ring and an amino group connected by
two methylene
group.
Histamine plays an important role in gastric acid secretion and
functions as a
neurotransmitter and neuromodulator.
Newer evidence indicates that histamine also plays a role in
immune
functions and chemotaxis of white blood cells.
movement or migration of cells in response to the
concentration gradient of extracellular signals.
Chemotaxis
DISTRIBUTION
Animal Tissue
Plants
In many venom
Bacteria
Stinging Secretions
STORAGE SITE FOR HISTAMINE
Mast Cell
Basophil
ECL
Histamine is present in all tissues, but with high amounts found in
the
skin, GIT, and lung.
It is found in high concentration in (blank) or(blank) and
secretion of
mast cells , basophils , insect stings.
