Study Set Content:
Almost all mammalian tissue contains histamine in an amount
ranging from
100 μg/g.
Concentrations in plasma and other body fluids contains very low
amount, but in human (blank) it contains a
significant amount.
cerebrospinal fluid (CSF)
Tissues that contain large number of mast cells is found on the
skin,
bronchial tree, and intestinal mucosa.
Mast cells are especially rich at sites of potential tissue injury— nose,
mouth, and feet; internal body surfaces; and blood vessels,
particularly at
pressure points and bifurcations.
A second important nonneuronal site of histamine storage and
release is the (blank) cells of the fundus of
the stomach.
enterochromaffin-like (ECL)
The bound form of histamine is biologically (blank) many
stimuli can trigger the release of mast cell histamine, allowing the
free amine to exert its actions on surrounding tissues.
inactive,
Non-mast cell histamine is found in several tissues, including the
brain, where it functions as a
neurotransmitter.
Histamine is an amine, it is formed by decarboxylation of the amino
acid
l-histidine,
Histamine is an amine, it is formed by decarboxylation of the amino
acid l-histidine, a reaction catalyzed in mammalian tissues by the
enzyme
histidine decarboxylase.
Histamine is an amine, it is formed by decarboxylation of the amino acid l-histidine, a reaction catalyzed in mammalian tissues by the
enzyme histidine decarboxylase. Once formed, histamine is either
stored or rapidly inactivated.
In mast cells, histamine is stored in granules as an inactive complex
that is composed of
histamine and polysulfated anion heparin
In mast cells, histamine is stored in granules as an inactive complex
that is composed of histamine and polysulfated anion heparin along
with an
ionic protein.
that is composed of histamine and polysulfated anion heparin along
with an ionic protein. If histamine is not stored, it is rapidly
inactivated by
amine oxidase enzymes.
Most important pathophysiologic mechanism of mast cell
land basophil is
histamine release.
These cells, if sensitized by(blank)attached to
their surface membranes, degranulate explosively when
exposed to the appropriate antigen.
IgE antibodies
This type of release also requires
energy and
calcium.
Degranulation leads to the simultaneous release of (blank) that are stored together in the granules.
histamine, adenosine triphosphate (ATP), and other
mediators
All types of histamine receptors have (blank) and transduced extracellular signals by way of (blank) mediated second
messenger systems.
seven
transmembrane helical domains (7TM), G-protein
Some of histamines have wide range of pharmacologic effects
and are mediated by both (blank) receptors
H1 and H2
Histamine released by this mechanism is a mediator in
immediate (blank), such as hay
fever and acute urticaria.
(type I) allergic reactions
