Study Set Content:
receptors appear to have very important
chemotactic effects on eosinophils and mast cells.
H4
H1 location
Smooth muscle,
endothelial cells
H2 location
Gastric parietal cells
H3 location
Central Nervous
System
H4 location
Mast, eosinophil, T,
dendritic cells
GI gastric acid
secretion
H2
Acute allergic response
H1
Neurotransmitter
control
H3
Immune response
regulation
H4
is a powerful stimulant of
sensory nerve endings, especially those mediating pain and
itching.
Histamine
This (blank)is an important component of
the urticarial response and reactions to insect and nettle stings.
H1- mediated effect
play important roles in appetite and
satiety; antipsychotic drugs that block these receptors
cause significant weight gain
H1 and H3 receptors
play important roles in
modulating release of several transmitters in the
nervous system.
Presynaptic H3 receptors
H3 agonists reduce the release of (blank) transmitters in various areas of the brain and
in peripheral nerves.
acetylcholine, amine,
and peptide
injection or infusion of
histamine causes a (blank) in systolic and diastolic
blood pressure and an (blank) in heart rate.
decrease, increase
The blood pressure changes are caused by the direct
vasodilator action of histamine on arterioles and
precapillary sphincters; the increase in heart rate involves
both stimulatory actions of histamine on the heart and a
reflex tachycardia.
may also
occur during histamine administration, consistent with the
vasodilation
Flushing, a sense of warmth, and headache
In both humans and guinea
pigs, histamine causes
bronchoconstriction
In both humans and guinea
pigs, histamine causes bronchoconstriction mediated by
H1 receptors
are very sensitive to histamine.
Asthma patients
