Study Set Content:
Ther tails attach to mast cells and
basophils and, when triggered by an antigen, cause
the cells to release histamine and other chemicals
that cause an allergic reaction.
IgE
Antibodies or immunoglobulins are (nlank), these are
used by immune system to identify and neutralize foreign objects
(i.e pathogenic bacteria or viruses).
y-shaped proteins
Antibodies or immunoglobulins are y-shaped proteins, these are
used by immune system to identify and neutralize foreign objects
(i.e pathogenic bacteria or viruses). These immunoglobulins
recognizes a unique molecule of the pathogen called
antigen
Immunoglobulins are glycoprotein molecules produced by plasma
cells (white blood cells) called
B lymphocytes
μ (miu) chains
IgM
ε (epsilon) chains
IgE
α (alpha) chains
IgA
– δ (delta) chains
IgD
Certain (blank), including drugs such as morphine and
tubocurarine, can displace histamine from its bound form
within cells.
amines
This type of release does not require (blank)and is not
associated with mast cell injury or degranulation.
energy
Loss of granules from the mast cell also releases
histamine, since (blank) in the extracellular fluid
rapidly displace the amine from the complex.
sodium ions
Chemical and mechanical mast cell injury causes
degranulation and histamine release.
an experimental drug, selectively
releases histamine from tissue mast cells by an exocytotic
degranulation process requiring energy and calcium.
Compound 48/80
exerts its biologic actions by combining with specific
cellular receptors located on the surface membrane.
Histamine
Four different histamine receptors have been characterized and are
designated (blank). No (blank)have been found within these
major types.
H1-H4, subfamilies
All four receptor types have been cloned and belong to the large
superfamily of
G protein-coupled receptors (GPCR).
The structures
of the H1 and H2 receptors differ significantly and appear to be more
closely related to (blank) respectively,
than to each other.
muscarinic and 5-HT 1 receptors,
In the brain, H1 and H2 receptors are located on
postsynaptic
membranes,
whereas H3 receptors are predominantly
presynaptic
receptors are found mainly on leukocytes in the bone marrow
and circulating blood.
H4
