Healing by Second Intention

fibrin clot is larger, and there is more exudate and necrotic debris in the wounded area
Much larger amounts of granulation tissue are formed to fill a bigger gap caused by the larger area of deficit
At first a provisional matrix containing fibrin, plasma fibronectin, and type III collagen is formed then replaced by type I collagen
Wound contraction helps to close the wound by decreasing the gap between its dermal edges and by reducing the wound surface area.
Within 6 weeks, large skin defects may be reduced to 5% to 10% of their original size

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Histopathology Lecture (Examinations)