Study Set Content:
Basis of Immunogenicity
- Foreignness
- Degradability
- Molecular weight
- Structural Stability
- Complexity/Chemical composition
Recognized as non-self by an individual's immune system
Foreignness
What happens when the MW gets higher?
The more immunogenic it becomes
Approximately how many daltons is an excellent immunogen?
100,000 daltons or greater
if structure is unstable, the molecule will be a poor antigen
Structural Stability
Totally inert molecules are poor antigen
Structural Stability
The more complex are more effective antigens
Complexity/Chemical Composition
are relatively poor antigens due to their repeating structure
Lipids, carbohydrates, and nucleic acid
These are glycoproteins produced by the plasma cells after stimulation by an antigen which acts specifically against an antigen in an immune response
Antibodies
Consist of 5 plasma proteins
Protein Electrophoresis
What are the 5 plasma proteins consisting the Protein Electrophoresis
Gamma, betta, alpha 1, alpha 2, albumin
Primary function of antibodies
Protection
These are regions or sections in an antibody
Domain
high content of the amino acid PROLINE (proteinogenic ammino acid) and hydrophobic residues allow for flexibility of antibodies
Hinge (H) Region
Fragment of binding
Fab Region
Fragment of crystallization
Fc Region
The site of biologic activities
Fc Region
What are the site of biologic activities in the Fc Region
Complete fixation, Skin fixation, & Placental transfer
Ch
Constant Heavy
CL
Constant Light
