Liver Function Tests
Test that measure biosynthetic function of the
Liver
Coagulation factors:
Except for factor VIII, blood clotting factors are
exclusively synthesized in hepatocytes
T1/2 of factor VII- 6 hrs / Fibrinogen – 5days
(shorter than albumin)
Rapid turnover – thus
measurement of clotting
factors
is the single best acute measure of hapatic
synthetic function (in the
diagnosis and assessment
of liver function in acute parenchymal liver disease
)