Study Set Content:
a material or mixture prepared according to a particular formula
Formulation
- a mixture of chemicals that do not chemically react.
In Chemistry, Formulation
Formulation PURPOSE
• to achieve effects that cannot be obtained from its components when these are used singly • to achieve a higher degree of effectiveness • to improve handling properties and often safety for the user.
Pharmaceutical formulation is the multistep process where the()is mixed with all other components by considering the factors of() and becomes the final beneficial medicinal product.
active drug, particle size, polymorphism, pH, and solubility
Benefits and constraints of the () are the four basic components for a successful pharmaceutical formulation.
active pharmaceutical ingredients (APIs), valuable excipients, associated interactions, and manufacturing procedure
• The formulation often functions in a way that includes different
dosage forms.
is the pharmaceutical drug product as marketed for use with a specific mixture of active ingredients and inactive components.
dosage forms
Characterized by low aqueous solubility, present a formidable challenge in achieving effective delivery and absorption within the human body
Lipophilic drugs
Lipid-based formulations are designed to address the challenge of () by enhancing the drug's solubility in lipids, making it more ()
poor solubility, bioavailable.
Hydrophilic antibiotics class
B-Lactams
Glcopeptides
Aminoglycosides
Oxazolidinones
B-Lactams
-Penicillins
-Carbapenams
-Monobactams
-Cephalosporins
Examples Penicillin
Piperacillin
Carbapenams
Meropenem
Monobactams
Aztreonam
Cephalosporins
Ceftriaxone
Glycopeptides example
Teicoplanin and Vancomycin
Aminoglycosides
Gentamicin and Amikacin
Oxazolidinones
Linezolid
Lipophilic antibiotics class
Fluoroquinolones
Macrolides
Glycylcyclines
Lincosamides
Examples
Fluoroquinolones
Ciprofloxacin
Moxifloxacin
