Study Set Content:
Macrolides
Clarithromycin
Azithromycin
Glycylcyclines
Tigecycline
LIncosamides
Clindamycin
Mostly renal excretion
Hydrophilic antibiotics
Mostly hepatic excretion
Lipophilic antibiotics
Minimally effected by third-spacing, hypoalbuminaemia and inotropes
Lipophilic antibiotics
Risk of underdosing by third-spacing, hypoalbuminaemia and inotropes
Hydrophilic antibiotics
are typically directly excreted by the kidneys, while
Hydrophilic drugs
undergo biotransformation before excretion
Hydrophobic drug
Examples (Hydrophilic
acetaminophen, valproic acid, ketoprofen, disopyramide, verapamil, and metoprolol.
ASA (ACETYLSALICYLIC ACID) exhibits
analgesic, anti-inflammatory, and antipyretic properties
It is a selective and irreversible inhibitor of cyclooxygenase-1 (COX-1)
ASA (ACETYLSALICYLIC ACID)
. It is a selective and irreversible inhibitor of cyclooxygenase-1 (COX-1) enzyme resulting in direct inhibition of the biosynthesis of () from arachidonic acid
prostaglandins and thromboxanes
ASA (ACETYLSALICYLIC ACID) also inhibits
platelet aggregation.
• Hypersensitivity to
aspirin or other NSAIDs.
Contraindications ASA (ACETYLSALICYLIC ACID)
Peptic ulcer, hemorrhagic disease, coagulation disorder, gout.
Severe() impairment.
hepatic and renal
Children () years and recovering from()infection.
Contraindications to what women
• Pregnancy and lactation.
(doses () daily during 3rd trimester)
>100mg
