Study Set Content:
Oral, IM, Sublingual, buccal, SC, dermal, rectal
and nasal routes.
EXTRAVASCULAR ADMINISTRATION
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To enter blood, a drug administered extravascularly must
be absorbed from the
site of administration
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– the ability to adjust a dose, alter the dosage
form, alter the frequency and route of administration are related to
the drug concentration-time relationship in the body; and
Pharmacokinetic
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the drug concentration at sites of action is
related to the magnitude of effects produced.
Pharmacodynamic-
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THE RULE OF FIVE
A molecular weight less than 500
✓ No more than five hydrogen bond donor groups
✓ No more than 10 hydrogen bond acceptor groups
✓ A calculated log P less than +5
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