With Endo’s interest and background, he searched for fungi that would block this enzyme. In 1973, Endo found a substance made by the mold Penicillium citrinum that was a potent inhibitor on the enzyme needed to make cholesterol; it was named compactin (mevastatin) With the collaboration of (blank), a physician treating patients with extremely high cholesterol due to a genetic defect

Akira Yamamoto

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Medchem Lecture

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