Study Set Content:
sterile suspension of inactivated poliomyelitis virus of types 1, 2, and 3
(trivalent vaccine)
virus strains are grown separately in primary cultures of
Rhesus monkey kidney tissues;
is used to kill the viruses
formaldehyde
first transmitted and isolated poliomyelitis virus experimentally in monkeys
Landsteiner and Popper
Landsteiner and Popper first transmitted and isolated poliomyelitis virus experimentally in monkeys when
1908:
originated a method of cultivating polio virus in vitro on animal tissues other than nervous tissue; awarded the Nobel Peace prize
Dr. John Enders
Dr. John Enders originated a method of cultivating polio virus in vitro on animal tissues other than nervous tissue; awarded the Nobel Peace prize when
1948
perfected the roller-coaster method of polio virus culture and the final detoxified form of polio vaccine
Dr. Jonas Salk
Dr. Jonas Salk when
1953:
POLIOVIRUS VACCINE LIVE ORAL
trivalent oral polio vaccine (TOPV)
preparation of one or a combination of the 3 types of live, attenuated polioviruses
POLIOVIRUS VACCINE LIVE ORAL
The manufacture of poliovirus vaccine live oral is similar to that of poliovirus vaccine inactivated (Salk), However, the viruses are not killed by treatment with formaldehyde, as is done with Salk vaccine; instead, the viruses are
attenuated.
manufactured and tested in a manner suited only for () and is free from any known microbial agent other than the attenuated poliovirus or polioviruses intended to be present
oral administration
of the University of Cincinnati,
Dr. Albert Sabin
of Lederle Laboratories
Dr. Harold Cox
of the Wistar Institute of Philadelphia
Dr. Hilary Koprowski
he attenuated live virus, when present in the intestinal tract, multiplies and produces a localized resistance to reinfection by the same type of virus, thus stimulating the production of type-specific() antibodies
serum
Generally frozen, stored at
-10°C
Vaccines containing live attenuated rubeola (measles) and rubella (German measles) viruses are available fo
active immunization
grown on cultures of either
avian embryo tissue or human diploid cell tissue
