Study Set Content:
Topical timolol may interact with orally
administered verapamil and increase the risk of
heart block
Approved for the treatment of glaucoma.
BETAXOLOL, CARTEOLOL, LEVOBUNOLOL,
AND METIPRANOLOL
has the potential advantage of being ß 1-
selective; to what extent this potential advantage
might diminish systemic adverse effects remains to
be determined.
Betaxolol
The drug apparently has caused worsening of
pulmonary symptoms in some patients.
Betaxolol
has been used extensively in patients
with thyroid storm
Propranolol
a it is used cautiously in patients with this condition
to control supraventricular tachycardias that often
precipitates
heart failure.
reduces the frequency and intensity of
migraine headache.
Propranolol
Other B-receptor antagonists with preventive
efficacy include
metoprolol atenolol, timolol, and
nadolol.
Since sympathetic activity may enhance skeletal
muscle tremor, it is not
• Surprising that antagonists have been found to
() certain tremors.
reduce
The somatic manifestations of anxiety may respond
dramatically to low doses of ()
particularly when taken prophylactically.
propranolol,
may contribute to the symptomatic
treatment of alcohol withdrawal in some patients.
Propranolol
is the most common adverse cardiac
effect of Bblocking drugs. Sometimes patients note
coolness of hands and feet in winter.
Bradycardia
Central
nervous system effects include mild sedation, vivid
dreams, and rarely,
depression.
associated with the use of
nonselective agents commonly causes worsening of
preexisting asthma and other forms of airway
obstruction without having these consequences in
normal individuals.
Beta 2-receptor blockade
are generally well
tolerated in patients with mild to moderate
peripheral vascular disease, but caution is required in patients with severe peripheral vascular disease
or vasospastic disorders.
Beta 1 selective antagonists
Beta-receptor blockade () myocardial
contractility and excitability.
depresses
In patients with abnormal myocardial function,
cardiac output may be dependent on sympathetic
drive. If this stimulus is removed by 3 blockade,
cardiac decompensation may ensue. Thus, caution
must be exercised in starting a B-receptor
antagonist in patients with compensated
heart failure
A life-threatening adverse cardiac effect of a 3
antagonist may be overcome directly with
isoproterenol or glucagon
A very small dose of () (eg, 10 mg of
propranolol) may provoke severe cardiac failure in
a susceptible individual.
a 8 antagonist
Beta blockers may interact with the calcium
antagonist (); severe hypotension,
bradycardia, heart failure, and cardiac conduction
abnormalities have all been described.
verapamil
