Study Set Content:
1- Flashcard

Inner part of the adrenal gland, which secretes mainly epinephrine but also small amounts of norepinephrine.

(1) Adrenal Medulla

Click To Flip the Card
2- Flashcard

Drugs that affect receptors stimulated by norepinephrine or epinephrine.

Adrenergic drugs

Click To Flip the Card
3- Flashcard

Drugs that mimic or stimulate the adrenergic nervous system or the actions of epinephrine or norepinephrine

(3) Sympathomimetics

Click To Flip the Card
4- Flashcard

Drugs or endogenous catecholamines that activates a and/or B receptors. These drugs are also known as sympathomimetics.

(4) Adrenergic Agonist

Click To Flip the Card
5- Flashcard

they directly interact with and activate adrenoceptors (eg. norepinephrine. and epinephrine)

(5) Direct agonists

Click To Flip the Card
6- Flashcard

their actions are dependent on their ability to enhance the actions of endogenous catecholamines.

(6) Indirect agonists

Click To Flip the Card
7- Flashcard





Click To Flip the Card
8- Flashcard

These indirect agents may have either of two different mechanisms:

(1) they may (blank) stored catecholamines from the adrenergic nerve ending(eg, the mechanism of action of tyramine),


Click To Flip the Card
9- Flashcard

(2) they may (blank) of released norepinephrine either by

➢(blank) of catecholamines already released (eg, the mechanism of action of cocaine and tricyclic antidepressants)

decrease the clearance, inhibiting reuptake

Click To Flip the Card
10- Flashcard

preventing the (blank) of norepinephrine(monoamine oxidase and catechol-O-methyltransferase inhibitors).

enzymatic metabolism

Click To Flip the Card
11- Flashcard

Some drugs have both

direct and indirect actions

Click To Flip the Card
12- Flashcard

Ex. of indirect-acting adrenergic agonists:

• amphetamine

• tyramine

Click To Flip the Card
13- Flashcard

Ex. Of two mixed (direct and indirect) agonists:

• Ephedrine

• Metaraminol

Click To Flip the Card
14- Flashcard

Ex. Of direct-acting adrenergic drugs

• Clonidine

• Dopamine

• Epinephrine

• Norepinephrine

• Isoproterenol

Click To Flip the Card
15- Flashcard

ultimately cause activation of adrenoceptors, leading to some or all of the characteristic effects of endogenous catecholamines.

Both types of sympathomimetics, direct and indirect,

Click To Flip the Card
16- Flashcard

The pharmacologic effects of direct agonists depend on the (blank), their relative (blank) for adrenoreceptor subtypes, and the relative (blank) of these receptor subtypes in target tissues.

route of administration, affinity, expression

Click To Flip the Card
17- Flashcard

The pharmacologic effects of____ sympathomimetics are greater under conditions of increased sympathetic activity and norepinephrine storage and release


Click To Flip the Card
18- Flashcard


• The effects of catecholamines are mediated by

cell-surface receptors.

Click To Flip the Card
19- Flashcard

Adrenoceptors are typical

G protein-coupled receptors (GPCRs).

Click To Flip the Card
20- Flashcard

The receptor protein has an extracellular ____, traverses the membrane seven times (transmembrane domains) forming three extracellular and three intracellular loops, and has an intracellular C terminus.


Click To Flip the Card
thumb_up_alt Subscribers
layers 243 Items
folder Medicine Category
0 Reviews
Share It Now!