Study Set Content:
contributes to the increased risk of vascular disease and sudden coronary death. It also probably contributes to the high incidence of ulcer recurrences in smokers with peptic ulcer.
Nicotine
Several approaches to help patients stop smoking:
Nicotine replacement therapy
Varenicline
in the form of gum, transdermal patch, nasal spray, or inhaler. Their action derives from slow absorption of nicotine that occupies α4ß2 receptors in the central nervous system and reduces the desire to smoke and the pleasurable feelings of smoking
Nicotine replacement therapy
a synthetic drug with partial agonist action at α4ß2 nicotinic receptors. use is limited by nausea and insomnia and exacerbation of psychiatric illnesses, anxiety, depression, and suicidal ideation
Varenicline
Acute intoxication the dominant initial signs:
Muscarinic excess:
Central nervous system involvement
miosis, salivation, sweating, bronchial constriction, vomiting, and diarrhea
Muscarinic excess:
rapidly, accompanied by peripheral nicotinic effects, especially depolarizing neuromuscular blockade.
Central nervous system involvement
Therapy: 1. maintenance of vital signs-respiration in particular may be
impaired
(blank) to prevent further absorption - (blank) of all clothing and washing of the skin in cases of exposure to dusts and sprays
. decontamination, removal
atropine parenterally in large doses, to control signs of muscarinic excess. treatment with (blank) for seizures.
pralidoxime & benzodiazepines
