M2 Location
Heart, nerves, smooth muscle
M3 Location
Glands, smooth muscle, endothelium
M4
CNS
M5
CNS
Nm
Skeletal muscle neuromuscular junction
Nn
CNS, postgang lionic cell body, dendrites
M1
Seven transmem brane segments, Gq/11 protein-lin ked
M2
Seven transmem brane segments, Gi/o protein-lin ked
M3
Seven transmem brane segments, Gq/11 protein-linked
M4
Seven transmem brane segments, Gi/o protein-linked
M5
Seven transmembrane segments, Gq/11 protein-linked
Nm
Pentamer1 [(α1)2β1δ γ)]
Nn
Pentamer1 with α and β subunits only, eg, (α4)2(β2) 3 (CNS)or α3α5(β2)3 (ganglia)
M1 Postreceptor mechanism
IP3, DAG cascade
M2
Inhibition of cAMP production, activation of K+ channels
M3
IP3, DAG cascade
M4
Inhibition of cAMP production
M5
IP3, DAG cascade
Nm
Na+, K+ depolarizing ion channel
Nn
Na+, K+ depolarizing ion channel