Study Set Content:
Constant diameter
Fixed bed cone
Constant Height
Free standing cone
25-30
Excellent
36-40
Fair
31-35
Good
41-45
Passable
56-65
Very poor
46-55
Poor
>=
Very very poor
Knowledge and control of the size and the size range of particles are of profound importance in
pharmacy
Thus, size, and hence surface area, of a particle can be related in a significant way to the
physical, chemical, and pharmacologic properties of a drug
PHARMACEUTICAL APPLICATION
Release and dissolution
- Absorption and drug action
- Physical stability
- Dose uniformity
Study of Study of the rates of reaction and the mechanism by which these reactions occur.
Chemical Kinetics –
It is used to ascertain pharmaceutical
product stability and bioavailability.
Proper storage of drug products, providing beyond use dates for prescriptions, and the preparation and storage of
sterile products -
To ensure that the patient receives the correct dose of a drug, whatever form it is carried in, the rate of degradation of a drug must be
known
The velocity speed with which a reaction occurs.
Rate of Reaction (Degradation rate)
Depends on the reactant
concentration, temperature, and pH.
It is determined by the change in the concentration of the reactants or products as a
function of time.
The rate may be determined by the slowest or
rate determining step.
