Study Set Content:
substances that exists in more than 1 crystalline form
Polymorphism
They have different melting points, x-ray diffraction patterns and solubilities
Polymorphism
when a change from one polymorphic form to another is reversible
. Enantiotropic
A + B ↔A + B
Enantiotropic
when the transition takes place in one direction
Monotropic
A→ B
Monotropic
use as a suppository base
Theobroma oil/Cacao butter
18 ˚
. Unstable gamma form melt
22˚
Alpha form melt
– 26˚
Beta prime form melt
– 34.5˚
Stable beta form melt
is the lowest possible temperature to melt cacao and to prevent the crystal nuclei from destruction (35˚stable beta crystal destroy)
33˚
form II more active orally in human than form III which is more available in the market
Sulfameter
has a significant influence on the biologic activity
. Polymorphs of chloramphenicol palmitate
– 5 different forms and 4 are unstable in the presence of water duetocaking, heating or grinding under water.
. Cortisone acetate
antiestrogenic and antineoplastic drug used to treat breast cancer and post-menopausal symptoms
3. Tamoxifen citrate
– metastable polymorph (less organized)
Form A
– stable held by hydrogen bonding
Form B
-essential hormone for the development of female sex characteristics
Estrogens
Based on studies the crystals (4) forms found contain solvent molecules and classified as (blank) rather than polymorph.
solvates
