Study Set Content:
The process of (blank) involves the breaking of inter-ionic or intermolecular bonds in the solute the separation of the molecules of the solvent to provide space in the solvent for the solute, interaction between the solvent and the solute molecule or ion.
solubilization
VERY SOLUBLE
1-10
FREELY SOLUBLE
10-30
SOLUBLE
30-100
SPARINGLY SOLUBLE
100-1,000
100-1,000
1,000-10,000
VERY SLIGHTLY SOLUBLE
>10,000
INSOLUBLE
The (blank) in human body are significant in a pharmaceutical formulation
solubility processes
The 60 percent of human body is water; the (blank) are taken place in this medium in soluble form
biological and chemical reactions
Poor (blank) is likely to give rise to increased formulation difficulties during clinical development.
aqueous solubility
process by which a solid substance goes into solution and may be regarded as being composed of two consecutive stages:
DISSOLUTION
An (blank) between solid and solvent breaks up the solid crystal for crystalline substances and opens the amorphous lattice for amorphous substances
interfacial reaction
This creates cavities in the solvent, a so-called (blank), molecules of solid become molecules of solute.
phase change
The solute molecules are transported away from the interface through a boundary layer by means of
diffusion or convection
A system to differentiate the drugs on the basis of their solubility and permeability which restricts the prediction of using the parameters solubility and intestinal permeability.
BIOPHARMACEUTICS CLASSIFICATION SYSTEM
High Solubility — High Permeability
CLASS I
Low Solubility — High Permeability
CLASS II
High Solubility — Low Permeability
CLASS III
Low Solubility — Low Permeability
CLASS IV
