Study Set Content:
Many drugs and pharmaceutical
ingredients are
organic weak
electrolytes
is an important physicochemical
property and has extensive
physiologic implications
degree of ionization
more water-soluble but much less
soluble in lipid
ionized forms
have greater lipid solubility and are
more permeable to lipid membranes
unionized forms
any process that results in the
formation of charged ions from
neutral process
Ionization
the process of separation of one
discrete species, usually in either
gas or liquid phase
Dissociation
one that is capable of accepting
protons from the solute:
Protophilic(basic solvent)
proton donating compound and is
represented by acids:
Protogenic
act both proton acceptors and
donors:
Amphiprotic
neither accept nor donate protons
useful for studying the reactions of
acids and bases in the absence of
solvent effects
Aprotic
Water
Amphiprotic
Alcohol
Amphiprotic
Formic acid
Protogenic
Acetic acid
Protogenic
Acetone
Protophilic
Ether
Protophilic
Sulfuric acid
Protogenic
Liquid acid
Protogenic
Liquid ammonia
Protophilic
Acetic Acid
Amphiprotic
